RAF Typhoon FGR4s have joined forces with France's air force in a coordinated attack against an hidden munitions depot in Syrian territory operated by the Islamic State group (IS), as stated by the British defence ministry.
The facility, identified by reconnaissance, was thought to be storing arms and explosives, the statement said, and was positioned in mountains just above the ancient city of Palmyra in Syria's central region.
"The RAF jets used precision-guided Paveway IV munitions to target a several approach shafts providing entry to the depot... initial indications suggest the objective was successfully hit," the MoD said.
There was no sign of any civilian casualties in the strike late on Saturday and each participating jet returned safely, the ministry further stated.
The Typhoon FGR4s were supported by a Voyager tanker plane.
IS - alternatively referred to as Daesh - established jihadist rule over significant areas in Iraq and Syria until 2019.
"This action underscores British leadership, and commitment to work closely with our allies, to stamp out any resurgence of Daesh and their violent and radical beliefs in the area," the British Defence Secretary John Healey said.
RAF aircraft have performed patrols over Syria to "deter any attempted resurgence" of IS after its routing at the battle of Baghuz in 2019, the authorities noted.
"I extend gratitude to all the members of British forces participating in this operation for their skill and their valour," he added. "Including them were a great many British personnel on duty over the holidays. This action, to take out terrorist threats who pose a risk to our safety, demonstrates how UK forces are always on standby, continuously, protecting the UK domestically and strong abroad."
Last December, the American forces executed what it described as a "large-scale strike" against Islamic State objectives in the country, following an ambush killed two American soldiers and a local interpreter in the Palmyra area.
The UN reports Daesh still has between 5,000 and 7,000 combatants in Iraq and Syria.